Авторы: Кутузова П. А., ветеринарный врач-терапевт; Романек Е. А., ветеринарный врач ОРИТ. 
Ветеринарная клиника доктора Сотникова, г. Санкт-Петербург.
 
Целью данной статьи является детальное описание клинических проявлений лептоспироза у собак, течения этого заболевания, терапевтических подходов к его лечению и прогнозов, а также анализ ассоциированного с этим заболеванием вторичного гиперальдостеронизма на примере конкретного клинического случая.

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Список литературы:

1. Faine S., Adler B., Bolin C., et al. Leptospira and Leptospirosis. 2nd ed. Melbourne: MediSci, 1999.
2. Ganoza C. A., Matthias M. A., Saito M., et al. Asymptomatic renal colonization of humans in the peruvian Amazon by Leptospira. PLoS Negle Trop Dis, 2010.
3. Arbour J., Blais M. C., Carioto L., et al. Clinical leptospirosis in three cats (2001-2009). J Am Anim Hosp Assoc, 2012.
4. Klarenbeek A., Schuffner W. A. P. Appearance in Holland of Leptospira differing from Weil Strain. Nederlands Tijdschrift voor Geneeskunde, 1933.
5. Ellis W. A. Control of canine leptospirosis in Europe: time for a change? Vet Rec, 2010.
6. Ward M. P. Seasonality of canine leptospirosis in the United States and Canada and its association with rainfall. Prev Vet Med, 2002.
7. Ghneim G. S., Viers J. H., Chomel B. B., et al. Use of a case-control study and geographic information systems to determine environmental and demographic risk factors for canine leptospirosis. Vet Res, 2007
8. Werts C., Tapping R. I., Mathison J. C., et al. Leptospiral lipopolysaccha-ride activates cells through a TLR2-dependent mechanism. Nat Immunol, 2001.
9. Meri T., Murgia R., Stefanel P., et al. Regulation of complement activation at the C3-level by serum resistant leptospires. Microb Pathog, 2005.
10. Levett P. N. Leptospirosis. Clin Microb Rev, 2001.
11. De Brito T., Menezes L. F., Lima D. M., et al. Immunohistochemical and in situ hybridization studies of the liver and kidney in human leptospirosis. Virchows Archiv, 2006.
12. Mastrorilli C., Dondi F., Agnoli C., et al. Clinicopathologic features and outcome predictors of Leptospira interrogans Australis serogroup infection in dogs: a retrospective study of 20 cases (2001-2004). J Vet Intern Med, 2007.
13. Yang H. L., Jiang X. C., Zhang X. Y., et al. Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation. BMC Infect Dis, 2006. 
14. Major A., Schweighauser A. & Francey T. Increasing incidence of canine leptospirosis in Switzerland. Int J Environ Res Public Health, 2014. 
15. Nally J. E., Chantranuwat C., Wu X. Y., et al. Alveolar septal deposition of immunoglobulin and complement parallels pulmonary hemorrhage in a guinea pig model of severe pulmonary leptospirosis. Am J Pathol, 2004.
16. Greenlee J. J., Alt D. P., Bolin C. A., et al. Experimental canine leptospirosis caused by Leptospira interrogans serovars pomona and bratislava. Am J Vet Res, 2005. 
17. Kohn B., Steinicke K., Arndt G., et al. Pulmonary abnormalities in dogs with leptospirosis. J Vet Intern Med, 2010.
18. Greene E. C. Leptospirosis. In: Infectious Diseases of the Dog and Cat. 4th Ed. C. E. Greene. Elsevier, pp. 431-447, 2012. 
19. Schulz B. S., Seybold N., Adamik K. N., et al. Ileocolic intestinal intussus-ception in a dog with leptospirosis. Tierarztliche Praxis Ausgabe K: Kleintiere Heimtiere, pp. 403-405, 2010. 
20. Townsend W. M., Stiles J. & Krohne S. G. Leptospirosis and panuveitis in a dog. Vet Ophthalmol, 2006. 
21. Michel E., Kook P. H., Voss K., et al. [Generalized metastatic intestinal and cutaneous calcinosis in a Hovawart puppy with leptospirosis]. Schweiz Arch Tierheilkd, 2011.
22. Kohn B., Engelbrecht R., Leibord W. Clinical findings, diagnostics and treatment results in primary and secondary immune-mediated thrombocytopenia in the dog. Kleintierpraxis, 2000.
23. Geisen V., Stengel C., Brem S., et al. Canine leptospirosis infections – clinical signs and outcome with different suspected Leptospira serogroups (42 cases). J Small Anim Pract, 2007. 
24. Goldstein R. E., Lin R. C., Langston C. E., et al. Influence of infecting serogroup on clinical features of leptospirosis in dogs. J of Vet Intern Med, 2006.
25. Mastrorilli C., Dondi F., Agnoli C., et al. Clinicopathologic features and outcome predictors of Leptospira interrogans Australis serogroup infection in dogs: a retrospective study of 20 cases (2001-2004). J Vet Intern Med, 2007.
26. Baumann D. & Fluckiger M. Radiographic findings in the thorax of dogs with leptospiral infection. Vet Radiol Ultrasound, 2001. 
27. Jane E. Sykes et al. Updated ACVIM consensus statement on leptospirosis in dogs. J Vet Intern Med, 2023
28. Vieira M. L., Nascimento A. Virulent Leptospira interrogans induce cytotoxic effects in human platelets in vitro through direct interactions. Front Microbiol, 2020. 
29. Juliette Sone et al. Prospective evaluation of abdominal ultrasonographic findings in 35 dogs with leptospirosis. Vet Radiol Ultrasound, 2018. 
30. Alejandro Dominguez, Vijayadershan Muppidi, Stephen W. Leslie, Sonu Gupta. Hyperaldosteronism, 2024.
31. Birnbaum N. et al. Naturally acquired leptospirosis in 36 dogs: serological and clinicopathological features. J Small Anim Pract, 1998.
32. Rentko V. T., et al. Canine leptospirosis. A retrospective study of 17 cases. J Vet Intern Med, 1992.